Functionalization of <i>N</i>,<i>N</i>-Dialkylferrocenesulfonamides toward Substituted Derivatives

Despite the well-established pharmacological properties of aromatic sulfonamides and interest introducing ferrocene into drugs, have scarcely been studied. General synthetic methods using lithium bases to perform sulfonamide-directed deprotolithiation or “halogen dance” reaction are here reported for functionalization N,N-dialkylferrocenesulfonamides toward various polysubstituted derivatives. Postfunctionalization ferrocenyl iodides by cross-coupling lithium/iodine exchange reactions were also considered. Finally, ligand behavior new phosphines in palladium-catalyzed coupling was studied, outcomes viewed light DFT calculations.